It is 1973 and Jude - known to her friends as Toto - has just graduated from art school and moves into a house in a run-down part of Leeds. Jude is a chaotic wild child who flirts with the wrong kind of people, drinks too much and gets stoned too often. Never happy to stay in one place for very long, her restlessness takes her on hitchhiking jaunts up and down the country. Her best friend, Nel, is the only steady influence Jude has but Nel's life isn't as perfect as it seems.
Reports of attacks on women punctuate the news and Jude takes off again, suffocated by an affair she has been having with a married woman. But what she doesn't realise is that the violence is moving ever closer to home: there is Janice across the road who lives in fear of being beaten up again by her pimp and Nel, whose perfect life is coming undone at her boyfriend's hands. At the same time infamous murderers, Fred and Rosemary West, are stalking the country, on the lookout for girls like Jude.